Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Studies on the release of histamine from basophils. 3. Correlation between basophil reactivity to anti-IgE and blood eosinophilia

谷崎 勝朗 岡山大学医学部附属病院三朝分院内科
駒越 春樹 岡山大学医学部附属病院三朝分院内科
周藤 真康 岡山大学医学部附属病院三朝分院内科
御般 政明 岡山大学医学部附属病院三朝分院内科
森永 寛 岡山大学医学部附属病院三朝分院内科
中川 三郎 岡山大学医学部第2内科
貴谷 光 岡山大学医学部第2内科
木村 郁郎 岡山大学医学部第2内科
Histamine release from basophils induced by anti-IgE was examined in 14 asthmatic subjects with blood eosinophilia. The subjects were divided into two groups; group I (with blood eosinophilia, positive skin test and positive RAST to house dust) and group II (with blood eosinophilia, negative skin test to various allergens and negative RAST to house dust). 1. Serum IgE levels in group I were much higher than those in group II. 2. Maximum percent histamine release induced by anti-IgE was much higher in group I than in group II. 3. Dose-response curve of anti-IgE-induced histamine release in group I showed consistent increase as anti-IgE concentrations increased. while, dose-response curve in group II was very low. These findings suggested that blood eosinophilia in group I might be elicited relating to IgE-mediated reaction. However, mechanism causing eosinophilia in group II was not clear in the present study.
原著論文 (Original Papers)