Journal of Okayama Medical Association
Published by Okayama Medical Association

<Availability>
Full-text articles are available 3 years after publication.

ヒト悪性胸腺腫に関する研究 第2編 ヒト上皮型悪性胸腺腫細胞株(MT-TY株)のハムスターへの異種移植

池田 裕政 岡山大学医学部第二内科学教室
Thumnail 99_1063.pdf 2.21 MB
抄録
A continuous cell line, which was designated as MT-TY, was established from an explant culture of human malignant thymoma (epithelial type) in our laboratory. In the present study, for the purpose of making an animal model of human malignant thymoma, MT-TY cells were transplanted into antilymphocyte serum-treated newborn hamsters. The MT-TY line was serially transplanted for 7 passages. When 1.2-11.0×10(6) cells were inoculated intraperitoneally, all of the 22 experimental animals developed invasive tumors. Of the 22 hamsters, ascites and pulmonary metastases were found in 16 and 4 hamsters, respectively. Histological characteristics of the tumors in hamsters were similar to those of epithelial type of human malignant thymoma. This animal model would be useful for various studies of human malignant thymoma.
キーワード
human malignant thymoma cell line
heterotransplantation
ISSN
0030-1558
NCID
AN00032489