慢性骨髄性白血病における好塩基球の形態並びに機能に関する研究　第1編　急性転化の早期診断における好塩基球の臨床的意義について

The pathophysiologic role of basophils in CML has not been fully elucidated. In order to establish criteria for the early diagnosis of blastic crisis in CML and also to gain some information about the maturation of basophils in CML, the author observed light-microscopically the morphologic changes of basophils in CML using so-called basophilograms. Types I and II basophils in the basophilograms corresponded to mature basophils, whereas types III and IV corresponded mostly to immature cells (r=0.65, p<0.01). Type III and IV basophils amounted to more than 60% of all basophils in the blastic phase of CML. These findings indicated that the basophilogram is useful in the early diagnosis of blastic crisis in CML.