Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

B型慢性肝疾患における肝細胞膜表面免疫グロブリンの酵素抗体法による検討

坂本 裕治 岡山大学医学部第一内科学教室
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抄録
The distribution of IgG, IgA and IgM was studied immunohistochemically in liver from 43 patients with type B chronic liver disease (chronic persistent hepatitis: 8 cases, chronic aggressive hepatitis 2A : 11 cases, chronic aggressive hepatitis 2B : 20 cases, liver cirrhosis : 4 cases) in relation to the hepatitis B virus-related antigen/antibody system. In 7 cases of chronic hepatitis, hepatocytes with IgG on the cell surface were scattered or clustered in the liver tissue. All 7 cases showed positive intrahepatic HBcAg and severe hepatitic activity. Immunoelectron microscopy revealed HBcAg to be localized in the membrane of the endoplasmic reticulum and on the cell surface of the hepatocytes. These findings suggest that the IgG on the hepatocytes may recognize HBcAg expressed on the surface of the hepatocytes. However, the cell surface IgG was also observed in liver tissue of chronic hepatitis patients which was obtained after acute exacerbation and in which HBcAg positive hepatocytes were scarcely seen. In such cases, the cell surface IgG may recognize HBV-related antigens other than HBcAg, neoantigens or liver specific membrane antigen.
キーワード
B型慢性肝疾患
酵素抗体法
免疫グロブリン
HBs抗原
HBc抗原
ISSN
0030-1558
NCID
AN00032489