Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

アルコール性肝疾患における血清および肝フェリチンの動態に関する研究

杉山 明 岡山大学医学部第一内科学教室
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抄録
The kinetics of serum ferritin were studied in 42 male patients with alcoholic liver diseases (17 with alcoholic fibrosis, 10 with alcoholic hepatitis and 15 with alcoholic cirrhosis). In addition, the chromatic reaction of biopsied liver tissue to ferritin staining (PAP method) was examined and compared with serum ferritin levels and the iron-staining data. Serum ferritin levels in patients with alcoholic liver diseases, determined immediately after abstinence, were significantly higher than those in normal controls, although no significant difference was noted in serum ferritin among the different disease types. The serum ferritin levels decreased exponentialy after abstinence regardless of the disease type. There were positive correlations between serum ferritin and the intensity of hepatic hemosiderin and between the intensity of hepatic hemosiderin and hepatic ferritin. These correlations indicate that the ferritin level changes according to the amount of hepatic iron stores. These results indicate that hyperferritinemia of patients with alcoholic liver diseases reflects an increase in hepatic iron stores and that the escape of hepatic ferritin due to hepatocellular damage and the reduced clearance of serum ferritin are also related to hyperferritinemia.
キーワード
アルコール性肝疾患
血清フェリチン
肝フェリチン
肝ヘモジデリン
ISSN
0030-1558
NCID
AN00032489