Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

モノクロナール抗体結合制癌剤に関する研究 第2編 抗HLAモノクロナール抗体結合代謝拮抗制癌剤(サイトシンアラビノシド,メソトレキセート)の作製とその生物活性

眞鍋 雄一 岡山大学医学部第2内科
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抄録
The anticancer agents 1-β-D-arabinofuranosylcytosine (ara-C) and methotrexate (MTX) were linked covalently to murine monoclonal IgG(1) antibody (H-1) with the use of dextran T-40. H-1 alone did not inhibit cell growth. The ara-C-(H-1) conjugate showed weaker cytotoxicity to an HLA-lacking cell line than ara-C, while ara-C-(H-1) and ara-C showed the same cytotoxicity to HLA-bearing cells. The MTX-(H-1) canjugste showed stronger cytotoxicity to HLA-bearing cells than MTX, while MTX-(H-1) and MTX showed the same cytotoxicity to cells lacking HLA. These results indicate that ara-C-(H-1) and MTX-(H-1) exert antibody-targeting cytotoxicity in vitro.
キーワード
抗HLAモノクロナール抗体
methotrexate (MTX)
cytosine arabinoside (ara-C)
ISSN
0030-1558
NCID
AN00032489