Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

ヒト正常脳及び脳腫瘍組織におけるS-100蛋白の局在に関する免疫組織化学的研究

大西 林吉 岡山大学脳神経外科学教室
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抄録
The localization of S-100 protein, a nervous system specific protein, was studied immunohistochemically in sections of normal human brain and various brain tumors. In human brain, the specific positive reaction for S-100 protein was observed in astrocytes, oligodendrocytes, ependymal cells and epithelial cells of the choroid plexus. In human brain tumors, a positive reaction was observed in all cases of astrocytoma, glioblastoma, oligodendroglioma, ependymoma, choroidplexus papilloma, neurinoma and teratoma examined. A positive reaction was also observed in some cases of meningioma and hemangioblastoma. In astrocytoma and glioblastoma, the positive reaction for S-100 proten was weak in intensity and heterogeneous throughout the section in accordance with the increased histopathological malignancy. All metastatic brain tumors were negative for S-100 protein. From this immunohistochemical evidence it is concluded that the immunohistochemical examination of S-100 protein in human brain tumors may become a useful method for the diagnosis of human brain tumors, especially in relation to the histogenesis and degree of malignancy.
キーワード
S-100蛋白
ヒト正常脳
ヒト脳腫瘍
免疫組織化学
ISSN
0030-1558
NCID
AN00032489