Journal of Okayama Medical Association
Published by Okayama Medical Association

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多核白血球および血清におけるβ-Glucuronidase, N-Acetyl-β-Glucosaminidase活性に関する研究 第1編 糖尿病患者について

石田 誠 岡山大学医学部第2内科教室
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抄録
β-Glucuronidase (β-G) and N-acetyl-β-glucosaminidase (NAG) activities were investigated in diabetic patients. Serum β-G activity, NAG activity, total cholesterol (TC), triglyceride (TG) and atherogenic index (A.I.) were significantly higher in diabetics than in controls. In diabetics, there were significantly positive correlations between serum β-G activity and fasting blood glucose level, TC, TG and A.I., and between serum NAG activity and fasting blood glucose level, TC and TG. Serum β-G and NAG activities were significantly higher in diabetics with hyperlipidemia than in diabetics without hyperlipidemia. The elevation of serum β-G and NAG activities in diabetics might be due to metabolic abnormalities accompanying hyperglycemia and hyperlipidemia. Serum NAG activity was significantly higher in diabetics with nephropathy than in those without nephropathy. β-G activity of polymorphonuclear leukocytes (PMN) in poorly controlled diabetics was significantly lower than PMN-β-G activity in controls and fairly controlled diabetics. Degradation of mucopolysaccaride and glycoprotein might be impaired in poorly controlled diabetics, and this impairment might explain glycoprotein-deposition in diabetic microangiopathy and impaired bacteriocidal activity in diabetic leukocytes. PMN-β-G activity was significantly higher in diabetics with severe diabetic retinopathy (ScottⅢ-V) than in those with mild diabetic retinopathy (Scott I-Ⅱ). This data suggests that high PMN-β-G activity contributes to the establishment of diabetic microangiopathy.
キーワード
多核白血球
β-Glucuronidase
N-Acetyl-β-Glucosaminidase,
糖尿病
ISSN
0030-1558
NCID
AN00032489