Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

Prozime-10 (P-10)の抗炎症作用について 第2報 P-10の抗炎症作用機序(I)

牧 一雄 岡山大学歯学部口腔外科学第1講座
Thumnail 96_35.pdf 1.15 MB
抄録
After intravenous injection of Prozime-10 (P-10) into anesthetized dogs, plasma cortisol rose slowly and reached a maximum 3.5hr or later. With an increase in the dose of P-10 to 10mg/kg, the maximum cortisol concentration increased dose-dependently. When DEP-treated P-10 was injected, a similar release of cortisol occurred but much less prominently than that induced by a corresponding dogs of non-treated P-10. When slices of the dog adrenal cortex were exposed to P-10, no significant release of cortisol was noticed, although ACTH released cortisol markedly. When P-10 was injected (i.v.), a transient but significant increase in plasma histamine (Hi) was noticed. When the sliced tissues were exposed to various concentrations of Hi, cortisol output increased along with an increase in Hi concentration. It became evident that the cortisol release from the sliced tissues due to Hi was provoked via H(1) receptors.
キーワード
蛋白分解酵素
犬副腎皮質
ACTH遊離
コルチゾール
ヒスタミン遊離
ISSN
0030-1558
NCID
AN00032489