Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

全身性エリテマトーデスの末梢血リンパ球機能 第2編 B cell activationにおけるnull cell分画の意義

盛政 公明 岡山大学医学部第三内科学教室
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抄録
Activation of B lineage cells in systemic lupus erythematosus(SLE) has been indicated by the synthesis of IgG without mitogenic stimulation. In the course of this study, a cell population in SLE peripheral blood which synthesized DNA spontaneously and which fractionated into a null cell population was noticed. It was found that cells responsible for hyperproduction of IgG without any stimulation in vitro belonged to the null cell population, not to the sIg(+) cell population. The data suggested that both spontaneous IgG production and DNA synthesis might be performed by the same cell population in SLE. To test whether or not secreted IgG was synthesized by preactivated SLE peripheral blood lymphocytes, these cells were stained with FITC-labeled anti-human Ig antibodies. Significantly more cytoplasmic Ig(+) staining in SLE cells than in normal cells was found. These observations suggest that there was a small group of cells of B cell lineage in the SLE peripheral blood which was stimulated to proliferate and differentiate into a sIg(-) plasmablast line able to secrete IgG.
キーワード
systemic lupus erythematosus
spontaneous Ig synthesis
B cell activation
null cell fraction
ISSN
0030-1558
NCID
AN00032489