Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

C型ウイルスによる細胞融合の研究

大重 宗比古 岡山大学医学部癌源研究施設生化学部門
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抄録
1. Autoradiographic study of syncytium formation between rat XC cells and MuLV-producing cells indicated that the syncytium consisted of XC cells exclusively. Virusproducing cells did not coexist with XC cells in the syncytium. 2. Human cells which formed a syncytium in response to SSAV or BaEV were transformed cells and were not normal cells. SSAV induced over a narrower range of human transformed cells than BaEV. In nonhuman cultured cells, BaEV did not induce a syncytium at all as far as tested. On the other hand, SSAV induced a syncytium in XC, GMK and CV-I cells. Anti-SSAV serum specifically blocked syncytium formation by SSAV but not by BaEV. Similarly anti-BaEV serum specifically blocked syncytium formation by BaEV but not by SSAV. Therefore, syncytium formation is specific for each virus and there is no cross-neutralization between SSAV and BaEV.
キーワード
細胞融合
マウス白血病ウイルス
ヒヒ内在性ウイルス
サル内腫ウイルス
ISSN
0030-1558
NCID
AN00032489