Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

全身性エリテマトーデスにおける尿中の低分子蛋白 第1編 尿中遊離light chainに関する検討

難波 義夫 岡山大学医学部第三内科
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抄録
The concentration of urinary free light chains was measured in 61 patients with systemic lupus erythematosus (SLE) by single radial immunodiffusion. The concentration was significantly increased in these patients, and was associated with hypocomplementemia and a high level of antibody to DNA. It also correlated with the clinical disease activity of SLE. It is postulated that increased free light chain in the urine of SLE patients is derived mostly from increased synthesis of light chain rather than from increased breakdown of intact immunoglobulins or decrease of catabolism during renal insufficiency. The measurement of urinary free light chains may offer information for evaluating disease activity in SLE patients.
キーワード
全身性エリテマトーデス
遊離L鎖
ISSN
0030-1558
NCID
AN00032489