Journal of Okayama Medical Association
Published by Okayama Medical Association

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全身性エリテマトーデスにおけるIgG-Rheumatoid Factorに関する研究 ―赤血球凝集反応を利用して― 第1編 赤血球凝集反応の基礎的考察

三橋 康彦 岡山大学医学部第三内科学教室
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抄録
It has been difficult to detect IgG-rheumatoid factor (IgG-RF) by hemagglutination procedures. This difficulty was thought to be due to the size of IgG-RF being too small to break Z-potential on the red blood cell surface. Therefore, a new method for detection of IgG-RF in sera was devised using sheep red blood cells sensitized with rabbit gammaglobulin, and antihuman IgG antibody. Fundamental experiments were performed. The treatment of a few kinds of 19S-IgM hemagglutinins, i.e., heterophile antibody, anti-B antibody, cold agglutinin and IgMRF with 2-ME reduced hemagglutination activity. Furthermore, the addition of anti-IgM antibody restored that activity. These observations suggest that IgG-RF alone does not agglutinate sensitized sheep red blood cells, but that it might agglutinate them in the presence of antiIgG antibody.
キーワード
全身性エリテマトーデス
IgG-リウマチ因子
抗グロブリン試験
Z-potential
ISSN
0030-1558
NCID
AN00032489