Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

免疫反応下における好塩基球の形態学的研究 第1編 特異的抗原による好塩基球の形態学的変化の走査型電子顕微鏡観察

小林 誠 岡山大学医学部第2内科学教室
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抄録
Fine morphological changes in blood basophils were examined in 3 healthy controls and 8 atopic asthmatics --- 4 buckwheat allergy patients and 4 mite allergy patients --- by scanning electron microscopy after they had been exposed to specific antigens. The results were as follows. 1) Observation on cell morphology showed 3 different types of basophils; A) Sphericalshaped basophils with short microvilli, B) Pear-shaped basophils with extended flag-like pseudopodia, C) 'Swollen' type basophils over glass-plates. 2) Investigations on surface structures demonstrated 3 different changes: a) Hemispheric projections or spindle-shaped processes on the cell surface, b) Irregular shaped pores among short rod-shaped microvilli, c) Ruptured cell membranes in marked swollen basophils. 3) Basophils in healthy controls did not show any changes of surface structures and were spherical when P.S.S., buckwheat and mite extracts were added. Similar results were obtained with basophils from atopic patients when P.S.S. were added. 4) Basophils from atopic patients, or basophils from healthy controls after passively sensitized with IgE rich serum, were pear-shaped or 'swollen' with surface structural changes.
キーワード
好塩基球
脱顆粒
特異的抗原
走査電顕
気管支喘息
ISSN
0030-1558
NCID
AN00032489