Fifteen patients with head and neck malignant lymphomas have been treated with a combination of bleomycin, cyclophosphamide, oncovin (vincristine) and prednisolone (B-COP) in combination with radiotherapy since 1975. The results are discussed and compared with those of eleven patients treated with radiotherapy alone. Complete remission and its duration in stage II E were significantly superior to those treated with radiation alone. Toxicity, chiefly leukopenia, was generally tolerable and reversible. Although the number of cases and the follow-up period are inadequate as yet, this therapeutic regimen is a promising means of increasing the duration of remission and the survival of patients with head and neck malignant lymphomas.