The presence of catecholamine containing cells (chromaffin cells) in human skin was deter-mined by fixation with chromate-bichromate solution followd by post-staining and other methods. Some of the brown pigment granules in chromated dermis stained with Giemsa and toluidine blue showed similar staining properties to chromaffin cells in rabbit adrenal medulla treated in the same way. They also were seen in large numbers in nevus pigmentosus, especially in blue nevi, but were rarely seen in various lesions of Recklinghausen's disease nor in atopic dermatitis. Judging from other results, this dermal brown pigment is probably not catechol-amine but melanin or a degradation product of melanin. Other possibilities of the nature of the granules are discussed with special reference to lipid pigment.