Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

Beta-Adrenergic Blockadeの血行動態に与える影響―Alprenolol, PropranololおよびPractololの実験的比較検討

斉藤 大治 岡山大学医学部第一内科教室
田原 律哉 岡山大学医学部第一内科教室
平野 和博 岡山大学医学部第一内科教室
上田 稔 岡山大学医学部第一内科教室
前 律夫 岡山大学医学部第一内科教室
湊 武 岡山大学医学部第一内科教室
与那原 宣彦 岡山大学医学部第一内科教室
原岡 昭一 岡山大学医学部中央検査部
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Effects of alprenolol, propranolol and practolol on hemodynamics were studied in open-chest anesthetized dogs, and following results were obtained; Coronary blood flow was decreased accompanied with a rise in coronary vascular resistance following the administiation of the drug. Cardiac output and heart rate were decreased, and total peripheral resistance was elevated significantly. Practolol produced lesser changes in coronary and systemic hemodynamics than alprenolol or propranolol; especially lesser elevation in total peripheral resistance and smaller decrease in maximun blood flow of aorta.