Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

軟体動物巨大神経細胞の興奮性に対するvaso-active peptideの効果

竹内 宏 岡山大学医学部附属脳代謝研究施設機能生化学部門
森 昭胤 岡山大学医学部附属脳代謝研究施設機能生化学部門
横井 功 岡山大学医学部附属脳代謝研究施設機能生化学部門
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抄録
Two spontaneous firing giant neurones (TAN, tonically oscillating neurone and PON, periodically oscillating neurone) were identified in the subesophageal ganglia of Achatina fulica Ferussac. Effects of vaso-active peptides (substance P, physalaemin, eledoisin-related substance, neurotensin, bradykinin (B.K.), Lys-B.K., Met-Lys-B.K., angiotensin (A.G.) Ⅰ, A.G. Ⅱ, hypertensin, A.G. Ⅲ) were examined on the excitability of these two neurones. Physalaemin showed the excitatory effect on the TAN excitability. This effect was due to depolarizing the TAN neuromembrane. The critical concentration (in bath application) was about 5x10(-5)g/ml. All of amino acids, of which physalaemin consists, were ineffective on the TAN excitability. The other mentioned peptides than physalaemin were ineffective on the same neuromembrane. All of peptides examined in the present work were ineffective on the PON excitability. Effects of vaso-active peptides are considered to be selective in the neuronal level.
ISSN
0030-1558
NCID
AN00032489