農薬ドリン剤の循環器系機能に及ぼす作用 第1編 ドリン剤の末梢血管に対する作用

By studying the action of drin compounds on the peripheral blood vessels (Krakow-Pissemiski's method) of the rabbit ear, the author obtained the following results: 1. All the drin compounds (dieldrin, aldrin and endrin) induce a transitory dilatation of the extirpated peripheral blood vessels. But at high concentrations vasoconstriction is observed. 2. Atropine does not counteract the vasodilation by dieldrin. 3. With respect to the dilatation of peripheral blood vessels adrenaline acts antagonistically in contrast to the additive effect of acetylcholine. 4. Drin compounds act antagonistically against the vasoconstriction by barium chloride. It is considered that the mechanism of vasodilatation by these compounds is based on their direct action on the contractible muscle cells of the vessel walls