胸腺摘出の免疫能に及ぼす影響に関する実験的研究 特にその血中抗体に及ぼす影響について

Effects of the thymectomy at birth on immunological function, especially on humoral factor, were studied in mouse. The following results were obtained. 1. Changes in circulating lymphocytes were followed daily for fourty-five days after thymectomy. No increase of lymphocytes was observed in thymectomized mice, although ratio of lymphocytes/neutrophiles increased from two to three during growth in control gronp. 2. Changes in γ-globulin fraction were investigated by paper electrophoresis. No marked difference was found between thymectomized and control groups. 3. Anaphylactic shock was induced after sensitization with egg albumin added with hemophilus pertussis vaccine. There was found no difference in incidence and severity of shock except survival time from onset of shock to death between both groups. 4. The immunological response to foreign tumor transplant was studied using Yoshida and Hirosaki sarcoma of rat. Behavior of growth of tumor cells implanted into peritoneal cavity of mice was investigated. Three or four days prolongation of survival time of tumor cells was only observed in thymectomized group. These results show that suppressive effect of thymectomy at birth on immunological function is apparently relating ro cellular antibody, although perticipation of humoral antibody is not completely neglected.

学位番号 乙第192号