Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

マウス白血病の発生機構に関する実験的研究 第2編 X線照射によるRF系マウス白血病の発生に及ぼす胸腺及び脾摘出の影響

国定 岑生 岡山大学医学部平木内科教室
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抄録
With the object to elucidate the role played by thymus and spleen in radiation leukemogenesis, effects of thymectomy and splenectomy on the induction of leukemia in RF mice by X-ray-irradiation were studied, dividing lymphocytic leukemia into thymic type and non-thymic type. As the result it has been clarified that thymectomy mainly inhibits the occurrence of the thymic type lymphocytic leukemia while splenectomy on the occurrence of the non-thymic type lymphocytic leukemia. As for the mechanism of this inhibition, a discussion was made on the significance of thymus and spleen as the organs that are constituted of the cells most susceptible to neoplastic transformation. After both thymectomy and splenectomy not a single mouse developed leukemia when exposed to X-ray-irradiation.
ISSN
0030-1558
NCID
AN00032489