実験的ビールス性肝炎の免疫血清学的研究 第2編 感染アレルギーにおける臓器細胞の反応性に関する免疫血清学的検討

Cell reactibilities of various organs during the course of infectious allergy were investigated, and the following results were obtained: 1) When a small amount of Ectromelia virus inoculated to produce subclinical infection, changes in reactibilities such as accelerated reaction of the parenchymal cells of viral hepatitis liver were observed by a phase-contrast microscope under supravital conditions when the autoliver antibody appeared in the blood at the later stage of the infection. This suggested a phenomenon of auto-organ allergy in the cells produced by infection. 2) In view from the attitude towards various antigens, such changes in the reactilities of the parenchymal liver cells during the course of auto-organ allergy were considered to be a part of generalized sensitization at this stage. Therefore, the presence of cell fixed antibody cannot be denied. 3) For the purpose of investigating the biological meaning of the auto-liver antibody its direct influence on the normal parenchymal liver cells under a supravital condition, passive sensitization and homologous liver sensitization were studied, Then it was revealed in every experiment that the auto-liver antibody gave an unfavorable effect on the parenchymal liver cells. Even low titer antibody gave a latent damage as a localizing factor, showing a cytotoxin-like reaction. The higher the titer of the auto-liver antibody, the more severe damage of the liver observed. 4) There was no essential differenee in biological value between two types of auto-liver antibody, the one produced in the process of auto-organ allergy by direct viral infection and the other produced by sensitization by means of homologous liver antigen. 5) Degenerative changes of parenchymal liver cells produced by either addition of antigen to sensitized liver cclls or addition of auto-liver antiboty to normal liver cells were mostly due to antigen-antibody reaction in which complement was not always needed. However, in the latter case some exhibited an evidence of latent damage due to cytotoxin-like mechanism.