運動負荷が放射線障害に及ぼす影響に関する実験的研究 第1編 放射線照射後の連続的運動負荷が生存率,体重変化及び血液諸成分に及ぼす影響

Guinea pigs were divided into the next four groups for the purpose of examining the effects of exhaustive physical exercise and fatigue after exposing to X-ray. (1) Non treated group (C) (2) Exercised control group (EC) (3) Radiated control group (RC) (4) Radiated exercised group (RE) The X-ray apparatus was operated at. 200 KV, 15 mA, 0.5 mm Copper and 0.5 mm Alminium filtration, 50 cm focus target distance. The dose was 200 r of. X-ray whole body irradiation in dose rate of 80.6 r/min (in the air). Subjects of this experiment were given 30 successive days of swimming at the rate of 30 minutes per day and 5 days per week. The results are as follows: (1) The 30 days survival rate of RE was lower than that of RC. (2) The decreasing rate of the body weight in RE was a little higher than that in RC. (3) The prolongation of the blood clotting time in RE was greater than that in RC. (4) The decreasing rate of red cell count in RE was a little higher than that in RC. In both groups the decreasing rate was the highest on the 14th day after the treatment. (5) The decreasing rate of hemoglobin content in RE was a little higher than that in RC. In both groups the decreasing rate was the highest on the 14th day after the treatment. (6) Reticulocyte count in RE and RC decreased in the beginning, but increased extremely on the 21st day after treatment. Its increasing and decrasing rate in RE was little different from that in RC. (7) The increasing rate of Heinz body in RE was higher than that in RC. (8) The decresing rate of white cell count in RE was not significantly different from that in RC. In both groups the white cell count was at minimum on the 14th day after treatment. (9) Concerning the classification of white cell, i.e. basophile., eosinophile-, neutrophile leucocyte, lymphocyte and monocyte, RE was not significantly different from RC. (10) About the changes of plasma proteins, a) The total protein in RC decreased a little in the beginning, but slightly increased in the latter period. That in RE showed little change in the beginning, and slightly increased in the latter period. Difference between RE and RC was not significant, b) A/G ratio did not change much in the beginning in RC as well as RE, but in the latter period it decreased in RC while increased in RE. c) Albumin didn't show much change in the beginning both in RC and RE, but it decreased a little in the latter period where as in RC it increased in RE. d) α-globulin in RC and RE increased a little after the treatment. Difference between RC and RE was not significant. e) β-globulin in RC decreased a little in the beginning, but increased in the latter period. On the contrary in RE, it decreased extremely in the latter period. f) Fibrinogen in RC and RE increased. Difference between RC and RE was not significant. g) γ-globulin n RC and RE decreased in the beginning. That in RC increased extremely, while in RE continued to decrease in the latter period.