腸チフス，パラチフスA，B並びに大腸菌毒素の骨髄培養に及ぼす影響について 第2編 腸チフス，パラチフスA，B並びに大腸菌毒素の家兎骨髄内偽好酸球及び人骨髄内好中球に及ぼす影響について―遊走速度，墨粒貪喰能，生体染色―

By loading toxins of S. typhi, S. paratyphi A, B, and E. coli to the bone-marrow tissue culture of normal rabbits the author observed the influences of these toxins on the wandering velocity, carbonparticle phagocytosis, and vital staining by neutral red, and next by loading toxins of S. typhi and E. coli to the bone-marrow tissue culture of normal persons studied the influences on the wandering velocity of neutrophils; and still further by adding the serum of the patient with typhoid fever to the bone-marrow tissue culture of normal rabbits pursued the influences on the wandering velocity of pseudoeosinophils; and obtained the following results. 1. The inhibitory action of these toxins on the wandering and carbon-particle phagocytosis decreases in the order of that of S. typhi, S. paratyphi A and S. paratyphi B, and the toxin of E. coli has hardly any such action. In addition, each of these toxins at a certain concentration accelerates the carbon-particle phagocytosis. 2. There can be recognized no difference between the action of toxins of S. typhi and E. coli on the wandering velocity of the neutrophils in the bone marrow of normal persons and the same on the wandering velocity of the pseudoeosinophils in the bone marrow of normal rabbits. 3. The influences exerted on the vital staining of the pseudoeosinophils in the bone marrow of normal rabbits are exactly identical with those on the carbon-particle phagocytosis and the wanderirg velocity, and the intensity of inhibitory action of these toxins on the cell functions decreases in the order of S. paratyphi A, B, and E. coli. 4. From these it has been clarified that the toxin of S. typhi acts directly on the bone marrow and disturbs the cell function of neutrophils and pseudoeosinophils; and likewise the toxin of S. paratyphi A and B impairs these functions to the degree next to that of S. typhi; whereas the toxin of E. coli has hardly no such inhibitory action. 5. In the serum of the patient with typhoid fever there can be recognized a factor that inhibits the wandering velocity of pseudoeosinophils in the bone marrow of normal rabbits.