The influences of vitamin E on uric acid formation were investigated with normal male guinea pigs by the administration of 50 mg of vitamin E into seminal vesicles through vas deferens. The experiment was carried out on two groups, one was continuous (5 mg, 10 day) and the other was interval (10 mg, 5 times at every other day) administration. The concentration of uric acid in blood was determined at before administration and at 15, 30. 60 minutes, 3 hours and 5 hours respectively. 1. Both continuous and interval administration caused the increasing of uric acid concentration in blood comparing with saline administration in semial vesicles. 2. The mean uric acid concentration reached a peak at 10 days and at 15 to 60 minutes which was significantly higher in continuous administration.