The hemogram was daily observed on the mouse with the inoculation of liver emulsion of ectromelia virus in the change of inoculated dosis and region, and the comparative studies with the hemogram of epidemic hepatitis in human was studied. And the results were as follows. 1. Leukocytosis was remarkable at the maximum stadium in both of inoculated dosis and region, but the abnormality of leudocyte count was not observed in the cases with the scanty inoculated dosis or the inoculated regions except the intraperitoneal cavity. 2. On the classification of leukocyte, no special picture of neutrocyte and lymphocyte was observed on all the cases with normal leukocyte count, but the tendency of neutrocytosis and it's left shift was observed on the cases with leukocytosis and young neutrocyte was observed on the cases with remarkable leukocytosis, besides, leukemoid reaction including the appearance of erythroblast was sometimes observed on the same cases. 3. Monocytosis, plasma cells and plasmoid cells in most of cases, and reticulocyte in a few case was found since the early stadium, even though some difference was observed on each of inoculated cases. 4. The sign of monocytosis and the apperence of plasma cells was observed on the stadium without the anatomical change of liver and spleen and it was noticed that the blood reaction as a reaction of whole body preceded to the pathologic change of liver and spleen. 5. These changes were very similar to the hemogram of epidemic hepatitis in human and it was thought that was the strong results of animal experiment for presuming the pathologic change of epidemic hepatitis.