The purpose of this report exists to clarify the influences of DOCA, cortisone, ACTH and glucuronic acid on the circulating plasma and blood volumes or the extracellular fluid volume in an experimental liver impairment by administering allyl formate to dogs, and the following results were obtained. 1. A subcutaneous injection of 2 mg/kg of DOCA, 20 mg/kg of cortisone or 2 International Units (I.U.)/kg. of ACTH at hour after a subcutaneous injection of allyl formate at 0.03 cc/kg, made the tendency of the decrease of the circulating plasma volume be inhibited to be genrally constant, the one of the increase of the extracellular fluid be also similarly inhibited to be finally decreased. 2. A similar injection of glucuronic acid did not influence on the circulating plasma volume or the extracellular fluid volume. 3. An intramuscular injection of 1 mg/kg of DOCA after a continuous subeutaneous
injection of allyl formate at 0.01 cc/kg for 5 days, introduced a tendency to accelerate the increase of the circulating plasma volume and the extracellular fluid volume. 4. A similar intramuscular injection of cortisone at 10 mg/kg or of ACTH at 1 I.U./kg did not influence on the circulating plasma volume and the extracellular fluid volume. 5. A similar intramuscular injection of glucuronic acid at 50 mg/kg did not influence on the circculating plasma volume, while it would more or less inhibit in some cases the decrease of the extracellular fluid volume.