Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

インヂカン定量に関する実験的研究 第一編 Jolles's反応の化学的本態に関する実験的研究

進東 勉 岡山大学医学部平木内科教室
68_589.pdf 847 KB
Out of the certain experimental results obtained in the isolation as well as synthesis of Thymolindogenide, which has been undertaken to determine certain products of Jolles's reaction in vivo, I could arrive at the following conclusions:- 1) For the first time in our literature, I have succeeded in isolating ccrtain color substances of Jolles's reaction, in the form of a red prismatic crystal whose melting point has proved as 234°~237℃. 2) The red prismatic cystal that thus has been isolated proves just the same in its chemical sense with the pure synthetic Thymolidogenide (that has its melting Point at 238°~240℃). 3) Color substances which I get from Jolles's and Jolles-Takeuchi's reactions have proved one and the same, both being Thymolindogenide. 4) Those Thymolindogenides which I myself have isolated as well as synthesized have higher melting points respectively, compared to Thymolindogenide synthesized by Jolles, by 16℃ or 20℃; moreover, dissolve themselves into crimson when they should have met withglacial acetic acid. 5) In an isolation test in which Jolles's or Jolles-Takeuchi's reactions were adopted, we could observe Indigo and certain non-crystal brown pigment, to be extracted simultaneously into the chloroform, besides Thymolindogenide. 6) In this, I have mentioned the synthetic method of producing the Thymolindogenide out of scanty amount of stuff.