Journal of Okayama Medical Association
Published by Okayama Medical Association

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ヘリコバクター・ピロリ感染による動脈硬化促進検討モデルとしてのapoe+/-ldlr+/-マウスの有用性

崔 錦花 岡山大学大学院医歯薬学総合研究科 病原細菌学
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抄録
Atherosclerosis is closely related to chronic infection. In the present study, we evaluated atherogenesis by gastric infection with Helicobacter pylori (H. pylori) in atherosclerosis-prone apoe+/-ldlr+/- mice. Six- week- old male apoe+/-ldlr+/- mice infected by H. pylori and apoe+/-ldlr+/- control mice were fed with a high cholesterol diet (1%). Eight weeks after the confirmation of infection, the extent of atherosclerosis, anti heat shock protein 60 of H. pylori (Hp-HSP60) serum titers, and the cellular immune responses against Hp-HSP60 were evaluated. Atherosclerosis was promoted by a Th1-mediated reaction against Hp-HSP60, accompanied by production of IFN-γ and IL-12, and mRNA expression of T-bet in the H. pylori -infected apoe+/-ldlr+/- mice. The over-expressed of HSP60 in stressed endothelial cells could be cross-recognized by T cells against Hp-HSP60 and contributed to the atherosclerosis. This mouse model would be useful for analyzing immunological mechanisms of atherogenesis.
キーワード
動脈硬化 (atherosclerosis)
ヘリコバクター・ピロリ (Helicobacter pylori)
熱ストレスタンパク60 (heat shock protein 60)
Tリンパ球 (T-lymphocytes)
apoe+/-ldlr+/-ヘテロダブルノックアウトマウス (apoe+/-ldlr+/- mice)
備考
原著
ISSN
00301558
NCID
AN00032489
DOI