Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

原発性胆汁性肝硬変肝組織における Fas 発現の免疫組織化学的検討

貴志 文俊 Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry
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抄録
The expression of Fas on the epithelial cells of bile ducts was examined in liver specimens from 10 patients with primary biliary cirrhosis (PBC), and 14 patients with chronic hepatitis by both light and electron microscopy using the indirect peroxidase-labeled antibody method. In all patients with PBC, Fas was observed on the surface of epithelial cells of interlobular bile ducts. By electron microscopy, electron-dense reaction products of Fas were detected on the basolateral plasma membrane of the bile duct epithelial cells, as well as on some membranes of the endoplasmic reticulum. Fas was expressed more strongly on the surface of the epitherial cells of interlobular bile ducts in PBC than of those in chronic hepatitis. These findings suggest that increased expression of Fas on such bila ducts may play some role in the pathogenesis of PBC.
キーワード
Fas
apoptosis
liver
primary biliary cirrhosis
immunoelectron microscopy
備考
原著論文
ISSN
0030-1558
NCID
AN00032489