Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

腎臓における副甲状腺ホルモン関連ペプチドの局在の検討

綾 邦彦 岡山大学医学部小児科学講座
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抄録
PTHrP mRNA was quantified by RT-PCR and the localization of PTHrP mRNA was determined by in situ hybridization in kidney. During development, the expression of PTHrP mRNA is much higher before 2 weeks of age while kidney is developing. In E16 fetal mice, PTHrP mRNA was strongly expressed in the collecting ducts, urothelium of the pelvis, tubles, the glomeruli and immature elements in the cortex of the developing kidney (nephrogenic zone). within 0-day-old-mice, it was dominantly expressed in collecting ducts, the urothelium of the pelvis and nephrogenic zone. These findings suggest that PTHrP plays a role in kidney development as an autocrine/ paracrine factor.
キーワード
副甲状腺ホルモン関連ペプチド(PTHrP)
腎臓
発達
in situ hybridization
備考
原著
ISSN
0030-1558
NCID
AN00032489