Journal of Okayama Medical Association
Published by Okayama Medical Association

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鉄欠乏性貧血の成因に関する研究―Puromycin aminonucleoside 投与腎障害に由来する実験的鉄欠乏状態の検討―

藤井 総一郎 岡山大学医学部第二内科学教室
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抄録
To clarify the pathogenesis of idiopathic iron deficiency anemia, small amounts of Puromycin aminonucleoside (PAN) which is known to be nephrotoxic, was administered repeatedly to induce continuous urinary iron excretion in rats. Urinary iron, serum iron, stored iron content and hemoglobin concentration were investigated. Urinary iron excretion was increased by PAN administration along with increased excretion of urinary transferrin. Consequently, a large amount of urinary iron seemed to be was observed with respect to continuous urinary iron excretion, manifesting normocytic hypochromic anemia at 13th week. These results suggest that prolonged loss of small amounts of iron through the urinary tract causes iron deficiency without alinical manifestation of ranal failure.
キーワード
urinary iron
renal injury
iron deficiency anemia
Puromycin aminonucleoside
rat
備考
原著
ISSN
0030-1558
NCID
AN00032489