Journal of Okayama Medical Association
Published by Okayama Medical Association

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気管支喘息におけるリンパ球機能に関する研究 第2編 気管支喘息における suppressor cell 機能の検討

武田 昌 岡山大学医学部第二内科学教室
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抄録
Cellular immunity in bronchial asthma has become essential for the regulation of various allergic reactions in the asthmatic attack. The function of peripheral blood lymphocytes of asthmatic patients was examined by the concanavalin A (Con A) induced suppressor cell assay. The suppressor activity of lymphocytes in mitogen-induced blastogenesis was shown to be decreased in patints with atopic and intractable asthma in comparison with the normal control. The suppressor activity in mite antigen induced lymphocyte blastogenesis was also decreased in patients with atopic asthma. Furthermore, the decrease of ConA induced suppressor activity correlated with the increase of serum IgE level in patients with atopic asthma. These findings indicate that the decreased suppressor cell activity is part of the mechanism of attack and may play an important role in the pathogensis of bronchial asthma.
キーワード
気管支喘息
ConA induced suppressor cell assay
Candida
mite
備考
原著
ISSN
0030-1558
NCID
AN00032489