Journal of Okayama Medical Association
Published by Okayama Medical Association

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Methyl isobutyl ketone の代謝と生物学的モニタリング 第2編 Methyl isobutyl ketone 暴露作業者の尿中代謝産物

廣田 直敷 岡山大学医学部公衆衛生学講座
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抄録
A field study on the metabolites of methyl isobutyl ketone (MIBK) in the urine of 20 workers who were exposed to mixed solvents containing MIBK, and in that of a subject exposed to pure MIBK with 3 separate control subjects were observed. One of the urinary metabolites, 4-methyl-2-pentanol (4M2P) was identified by gas chromatography-mass spectrometry only in the urine of workers exposed to MIBK. Time-weighted average concentration of the mixed solvents for 8 hours were as follows ; MIBK 21.9±15.1 ppm (m±SD), toluene 18.3±8.9 ppm, ethyl benzene 9.6±4.6 ppm, xylene (total) 18.9±12.5 ppm. The regression equation between MIBK concentration X (ppm) in air and 4M2P concentration Y (mg/g creatinine) in the urine was : Y=25X-10.25. Its correlation coefficient was 0.63. Thus the urinary concentration of 4M2P corresponding TLV (Threshould Limit Values : 50ppm) of MIBK was 2.61 (mg/g creatinine). In a subject exposed to pure MIBK, the time-weighted average concentration of MIBK for 6 hours was 42.3ppm and 4M2P concentration in the urine was 0.42 (mg/g creatinine).
キーワード
MIBK
ヒトの尿中代謝産物
4-メチル-2-ペンタノール
マスクロマトグラフィー
メチルイソブチルケトン
備考
原著
ISSN
0030-1558
NCID
AN00032489