Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

水銀イオン投与後の生体内運命に関する(DL)-α-トコフェロール及びアミノトリアゾールの影響(水銀の酸化及び還元に関する試験管内及び動物実験 第2編)

倉橋 康二郎 岡山大学医学部公衆衛生学教室
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抄録
Mice were preliminarily injected with Vitamin E subcutaneously and with mercuric ion intraperitoneally. The exhalation and organ distribution of mercury were determined and compared with the control mice without Vitamin E. Mice were preliminarily injected with 3-amino-l, 2, 4-triazole intraperitoneally and with mercuric ion intraperitoneally. The exhalation, urinary excretion and organ distribution of mercury were compared with the control mice. The results obtained were as follows. 1. The amounts of mercury in the exhalation of mice which were administered Vitamin E were more than the control. 2. The levels of mercury concentration and perecentages of distribution in the kidneys of mice which received Vitamin E were significantly higher than the control mice. The levels of mercury concentration and percentages of distribution in the carcass and the subcutaneous tissue of mice which received with Vitamin E were significantly less than the control mice, respectively. It suggested that the Vitamin E exerts an effect as the blocker, with accumulation of mercury in the adipose tissue and, eventually, a larger accumulation of kidney. 3. The amounts of exhaled mercury and that in urine in mice which received 3-amino-1, 2, 4-triazole were more than those in the control mice. This suggested that the reoxidation of mercury (Hg(0)→Hg(++)) in the mice treated with 3-amino-1, 2, 4-triazole was less than in control mice, and that higher amounts of Hg0 resulted, which could be exhaled from the lungs and accumulated into the kidneys.
キーワード
(DL)-α-tocopherol
3-amino-1, 2, 4-triazole
mercuric ion
mice
ISSN
0030-1558
NCID
AN00032489