Journal of Okayama Medical Association
Published by Okayama Medical Association

<Availability>
Full-text articles are available 3 years after publication.

急性腎不全ラットにおける肺内グアニジノ化合物の経日的変化に関する実験的研究

香曽我部 義則 岡山大学医学部麻酔・蘇生学教室
Thumnail 101_379.pdf 466 KB
抄録
Renal failure causes various metabolic disorders, especially increases of uremic toxins. Of the uremic toxins, guanidino compounds have a main role in uremia. Although lung injury is often complicated by renal failure, the role of guanidino compounds in lung injury is obscure. I have studied the changes in guanidino compounds in the lung of rat with ischemic acute renal failure. Guanidino compounds increased the first day after ischemia, but methylguanidine, which is the most toxic guanidino compound, showed a delayed increase in the lung. These results suggest the de novo synthesis of methylguanidine in the lung. A guanidinogram may by useful to judge changes in guanidino compounds.
キーワード
急性腎不全
グアニジノ化合物
メチルグアニジン
ISSN
0030-1558
NCID
AN00032489