Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

アカタラセミアマウスの血液および肝臓カタラーゼ活性の熱安定性 第2編 clofibrate投与時のアカタラセミアマウス肝臓カタラーゼ活性の熱安定性および血清酵素活性の変動

小柏 道子 岡山大学医学部公衆衛生学教室
Thumnail 101_999.pdf 1.23 MB
抄録
Normal and acatalasemic mice were fed 0.5% clofibrate (CPIB) for 70 days and variations of catalase activity and thermal stability of liver catalase were investigated. 1. The specific catalase activity (catalase activity/g liver weight) in the liver of mice which received CPIB compared to that of controls was calculated. The specific catalase activity was in 2.2 normal mice and 1.2 in acatalasemic mice. A significant increase of activity was recognized in normal mice but not in acatalasemic mice. 2. The specific catalase activity in the blood of mice which received CPIB to that of control was determined. The specific catalase activity was 1.3 in normal mice and 1.1 in acatalasemic mice. A significant increase was not observed in either kind of mice. 3. The heat stability of catalase in the liver of normal or acatalasemic mice which received with CPIB was higher than that of normal or acatalasemic mice which did not received CPIB. 4. Increased levels of ALP and ChE activities and decreased levels of GOT activity and TG concentration were observed in the normal or acatalasemic mice which received CPIB, compared to control mice. 5. Isozyme of ALP were determined by electrophoresis. Increased ALP in the plasma of normal and acatalasemic mice was thought to be derived from liver ALP.
キーワード
アカタラセミアマウス
clofibrate
カタラーゼ
熱安定性
ISSN
0030-1558
NCID
AN00032489