Journal of Okayama Medical Association
Published by Okayama Medical Association

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気管支喘息におけるカリクレイン-キニン系に関する研究 第1編 気管支喘息と末梢血力リクレイン-キニン系の活性化についての検討

髙井 豊 岡山大学医学部第二内科学教室
100_927.pdf 699 KB
発行日
1988
抄録
The relationship between bronchial asthma and Hageman factor dependent pathways (the contact phase of the internal coagulation system) was studied in reference to the possible role of the kallikrein-kinin system in asthmatics.The plasma Hageman factor level was significantly lower in asthmatics (74.8±27.7% in remission, and 75.4±26.3% during in attack) than in healthy subjects (98.1±27.6%), and the plasma prekallikrein value was also lower in asthmatics (88.8±25.3% in remission, and 75.1±23.8% during in attack) than in normal controls (105.7±19.7%). Especially, the plasma prekallikrein level was significantly lower in asthmatics during in attack than in those in remission. The plasma bradykinin level of asthmatics in remission tended to be higher (98.8±89.8pg/ml) than that of healthy subjects (47.1±29.6pg/ml). The plasma high molecular weight kininogen level was not significantly different between asthmatics and normal subjects. These results suggest that the plasma kallikrein-kinin system may play a role in the pathophysiology of bronchial asthma.
キーワード
bronchial asthma
Hageman factor dependent pathways
kallikrein-kinin system
atopic asthma
intractable asthma
ISSN
0030-1558
NCID
AN00032489