培養血管平滑筋細胞における脂質代謝に関する研究 第1編　細胞増殖と過酸化脂質生成に及ぼす抗酸化剤の影響について

The effects of antioxidants on cell proliferation and lipid peroxide formation of cultured aortic smooth muscle cells obtained from normal, hypercholesterolemic and aged rabbits were studied in vitro.α-Tocopherol and coenzyme Q(10) were used as antioxidants.The lipid peroxide content of cells was generated in a time dependent manner with cell proliferation, it remained within the cells and did not accumulate in the media.α-Tocopherol promoted cell proliferation and suppressed the intracellular lipid peroxide formation expressed in terms of DNA content.These effects were significant only in HL-SMC, and were not significant in NR-SMC or Aged-SMC. Coenzyme Q(10) did not effect cell proliferation or lipid peroxide formation.