浅野 孝
Department of Child Neurology,Okayama University Medical School
岡 鍈次
Department of Child Neurology,Okayama University Medical School
河原 道子
Department of Radiology,Okayama University Medical School
栄 勝美
Department of Radiology,Okayama University Medical School
平木 祥夫
Department of Radiology,Okayama University Medical School
大田原 俊輔
Kibi International University Health Sciences School
発行日
抄録
Proton Magnetic Resonance Spectroscopy (1H-MRS) can be used to detect cerebral metabolites including N-acetylaspartate (NAA),creatine (Cr) and choline (Ch). Hence,clinical applications of this method for neuropediatric diseases can be expected. However,regarding neuronal migration disorders,there have been only a few reported studies. We therefore examined the lH-MRS in six patients with migration disorders,ages ranged
from 8months to 28years 10months with a mean of 10years 10months. Investigation was performed using Magnetom H15 (Siemens) with a repetition time of 1500 msec and an echo time of 270msec. The ratio of NAA/Cr,Ch/Cr were examined. The volume of interest with the size of 2 × 2 × 2 ~ 3 × 3 × 5cm3 was chosen in the area including lesions,and a contralateral area without lesions was also investigated. Results were as follows. 1) The ratio of NAA/Cr was low in the area with lesions in all 6cases; 1.41,1.95,2.27 and 1.71 in cases with heterotopic gray matter,0.99 in one case with polymicrogyria,an d 1.30 in one
case with hemimegalencephaly,contrasted with a contralataral area without lesions: 1.89,
2.89,2.87,2.55,3.26,2.03,respectively. 2) The ratio of Ch/Cr showed no consistent difference
between the area including lesions and contralataral area without lesions. Our
findings of a decreased NAA/Cr ratio can be inferred to reflect the decreased numbers of
neuronal cell population,or reduced metabolism in the lesions.
キーワード
MR spectroscopy
migration disorder
heterotopic gray matter
polymicrogyria
hemimegalencephaly
ISSN
NCID
NAID
JaLCDOI