Acta Medica Okayama 73巻 2号
2019-04 発行

Exchange Transfusion and Cytarabine for Transient Abnormal Myelopoiesis in Hydrops Fetalis

Okamura, Tomoka Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Washio, Yousuke Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yoshimoto, Junko Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tani, Kazumasa Department of Obstetrics and Gynecology, Okayama University Hospital
Tsukahara, Hirokazu Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shimada, Akira Department of Pediatric Hematology/Oncology, Okayama University Hospital
Publication Date
2019-04
Abstract
Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.
Document Type
Case Report
Keywords
cytarabine
Down syndrome
exchange transfusion
hydrops fetalis
transient abnormal myelopoiesis
Link to PubMed
ISSN
0386-300X
NCID
AA00508441
JaLC DOI
DOI: