Acta Medica Okayama 71巻 2号
2017-04 発行

Adenomyomatosis Concomitant with Primary Gallbladder Carcinoma

Morikawa Tatsuya Department of Gastroenterological Surgery, Kochi Health Sciences Center
Okabayashi Takehiro Department of Gastroenterological Surgery, Kochi Health Sciences Center
Shima, Yasuo Department of Gastroenterological Surgery, Kochi Health Sciences Center
Sumiyoshi, Tatsuaki Department of Gastroenterological Surgery, Kochi Health Sciences Center
Kozuki, Akihito Department of Gastroenterological Surgery, Kochi Health Sciences Center
Saisaka, Yuichi Department of Gastroenterological Surgery, Kochi Health Sciences Center
Tokumaru, Teppei Department of Gastroenterological Surgery, Kochi Health Sciences Center
Sui, Kenta Department of Gastroenterological Surgery, Kochi Health Sciences Center
Iwata, Jun Department of Diagnostic Pathology, Kochi Health Sciences Center
Matsumoto, Manabu Department of Diagnostic Pathology, Kochi Health Sciences Center
Morita, Sojiro Department of Radiology, Kochi Health Sciences Center
Nishioka, Yutaka Department of Gastroenterological Surgery, Kochi Health Sciences Center
Publication Date
2017-04
Abstract
Some clinicians have proposed a relationship between gallbladder (GB) cancer and adenomyomatosis (ADM) of the gallbladder, although the latter condition is not considered to have malignant potential. We retrospectively reviewed the surgical pathology database of patients who underwent resection for ADM of the gallbladder at our institution from March 2005 to May 2015. In total, 624 patients underwent surgical resection of the gallbladder with Rokitansky-Aschoff sinuses. Of these cases, 93 were pathologically diagnosed with ADM of the gallbladder, with 44 (47.3%) classified macroscopically as fundal-type ADM, 26 (28.0%) as segmental type, and 23 (24.7%) as diffuse-type ADM. In 3 of the 93 (3.2%) resected specimens, early-stage GB carcinoma was detected, although preoperative imaging did not suggest a malignant neoplasm of the gallbladder in any of these patients. GB cancer subsequently developed in the mucosa of the fundal compartment distal to the annular stricture of the segmental-type ADM in 2 of these patients and against the background of the fundal-type ADM in 1 patient. This study revealed the difficulty of early diagnosis of primary GB cancer in the setting of concurrent ADM, and clinicians should be aware of this frequent coexistence.
Document Type
Original Article
Keywords
adenomyomatosis
gallbladder carcinoma
Rokitansky-Aschoff sinuses
surgery
carcinogenesis
Link to PubMed
ISSN
0386-300X
NCID
AA00508441
JaLC DOI
DOI:
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