ID 57725
フルテキストURL
著者
Iwamuro, Masaya Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Aoyama, Yuki Department of Gastroenterology, Kagawa Prefectural Central Hospital,
Suzuki, Seiyuu Department of Gastroenterology, Sumitomo Besshi Hospital
Kobayashi, Sayo Department of Internal Medicine, Fukuyama City Hospital
Toyokawa, Tatsuya Department of Gastroenterology, Fukuyama Medical Center
Moritou, Yuki Department of Internal Medicine, Hiroshima City Hiroshima Citizens Hospital
Hori, Shinichiro Department of Endoscopy, Shikoku Cancer Center
Matsueda, Kazuhiro Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
Yoshioka, Masao Department of Internal Medicine, Okayama Saiseikai General Hospital
Tanaka, Takehiro Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons
Okada, Hiroyuki Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
抄録
BACKGROUND:
Clinical characteristics and prognosis of patients with a solitary Peutz-Jeghers polyp (PJP) have not been fully investigated.
METHODS:
Solitary PJP was diagnosed when a single hamartomatous lesion was identified in the gastrointestinal tract of patients without mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome. We retrospectively reviewed 51 patients (32 men and 19 women) with a solitary PJP and analyzed the sex, age at diagnosis, endoscopic features, and outcomes in this patient group. The STK11/LKB1 germline mutation was not investigated in any of the patients.
RESULTS:
The mean age of the 51 patients was 66.1 years. The polyp was found in the duodenum (N = 10), jejunum (N = 2), cecum (N = 2), transverse colon (N = 5), sigmoid colon (N = 21), or rectum (N = 11). Most of the polyps presented as a pedunculated lesion (N = 40), followed by semipedunculated (N = 9) and sessile (N = 2) morphologies. The mean size of a solitary PJP was 15.6 mm (range: 5 to 33 mm). During a mean endoscopic follow-up period of 4.5 years (range: 0.1 to 16.1 years), no recurrence was identified. Eighteen of the enrolled patients had a history of cancer or concomitant cancer. Five patients died due to non-gastrointestinal-related causes. No additional cancer or death directly related to solitary PJP was observed.
CONCLUSIONS:
Solitary PJPs did not recur in this study. Although examination of the entire gastrointestinal tract using esophagogastroduodenoscopy, enteroscopy, and colonoscopy is desirable to exclude Peutz-Jeghers syndrome, follow-up endoscopy after endoscopic polyp resection may be unnecessary, once the diagnosis of a solitary PJP is made.
発行日
2019-09-08
出版物タイトル
Gastroenterology Research and Practice
出版者
Hindawi
開始ページ
8159072
ISSN
1687-6121
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
著作権者
Copyright © 2019 Masaya Iwamuro et al.
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1016/bs.aiip.2019.01.001
ライセンス
http://creativecommons.org/licenses/by/4.0/
Citation
Gastroenterology Research and Practice Volume 2019, Article ID 8159072, 5 pages https://doi.org/10.1155/2019/8159072
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