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ID 40738
フルテキストURL
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タイトル(別表記)
The influence of HCO(3) -induced and CO(2) -induced pH changes on the action of non-depolarizing muscle relaxants in rats
著者
長野 修 岡山大学医学部麻酔・蘇生学教室
抄録
The influences of HCO(3)-induced and CO(2)-induced pH changes on the action of nondepolarizing muscle relaxants (MRs) were investigated using a rat phrenic nervehemidiaphragm preparation. Changes in pH were induced by varying HCO(3) concentration of the modified Krebs' solution (mK') or by varying the CO(2) concentration in the gas aerating the mK'. Changes in [Ca(++)] and [Mg(++)], associated with changes in HCO(3) concentration, were measured and corrected. A change in HCO(3) from 50mM to 13.5mM or a change in CO(2) from 2.5% to 9%, augmented the partial neromuscular blockade produced by d-Tc or vecuronium (p<0.01), while inhibiting that produced by metocurine or pancuronium (p<0.01). A change in HCO(3) from 13.5mM to 50mM or a change in CO(2) from 9% to 2.5%, inhibited the partial neuromuscular blockade produced by d-Tc or vecuronium (p<0.01), while augmenting that produced by metocurine or pancuronium (p<0.01). These findings suggest that the HCO(3)-induced and CO(2)-induced pH changes have a similar influence on the action of MRs. A difference exists between mono- and bisquaternary MRs with regard to their response to pH changes.
キーワード
非脱分極性筋弛緩薬
代謝性pH変化
呼吸性pH変化
筋弛緩作用
発行日
1989-04
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
101巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
387
終了ページ
394
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/101/3-4/101_3-4_387/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
9
Eprints Journal Name
joma