ID | 31969 |
JaLCDOI | |
フルテキストURL | |
著者 |
Piao, Cheng-Yu
Okayama University
Fujioka, Shin-ichi
Okayama University
Fujio, Kozo
Okayama Hepatitis Research Group
Kaneyoshi, Toshihiko
Okayama Hepatitis Research Group
Araki, Yasuyuki
Okayama Hepatitis Research Group
Hashimoto, Kuniaki
Okayama Hepatitis Research Group(OHRG)
Senoh, Tomonori
Okayama Hepatitis Research Group
Terada, Ryo
Okayama Hepatitis Research Group
Nishida, Tomohiro
Okayama University
Kobashi, Haruhiko
Okayama University
Sakaguchi, Kohsaku
Okayama University
Shiratori, Yasushi
Okayama University
|
抄録 | Lamivudine is widely used to treat patients with hepatitis B. However, the outcomes in patients with hepatocellular carcinoma (HCC) treated with lamivudine have not been established. This study was conducted to evaluate the outcomes of lamivudine treatment for patients with HCC using an untreated, matched control group. Thirty patients with controlled HCC orally received lamivudine. As controls, 40 patients with HCC who were not treated with lamivudine and matched for clinical features were selected. The lamivudine-treated and untreated groups were compared with respect to changes in liver function, HCC recurrence, survival, and cause of death. In the lamivudine-treated group, there was significant improvement in the Child-Pugh score at 24 months after starting treatment, while no improvement was observed in the untreated group. There was no significant difference in the cumulative incidence of HCC recurrence and survival between the groups. However, there was a significant difference in the cumulative incidence of death due to liver failure (P= 0.043). A significant improvement in liver function was achieved by lamivudine treatment, even in patients with HCC. These results suggest that lamivudine treatment for patients with HCC may prevent death due to liver failure. Further prospective randomized studies using a larger number of patients are required. |
キーワード | liver failure
Child-Pughscore
recurrence
survival
resistant mutant
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2005-10
|
巻 | 59巻
|
号 | 5号
|
出版者 | Okayama University Medical School
|
開始ページ | 217
|
終了ページ | 224
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |