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ID 18090
Eprint ID
18090
フルテキストURL
80_399.pdf 5.26 MB
タイトル(別表記)
Immunological Studies on Systemic Lupus Erythematosus Part Ⅱ Experimental Production of Systemic Lupus Erythematosus (SLE)
著者
宮脇 昌 岡山大学医学部大藤内科教室
抄録
1. There were no changes suggestive of SLE in the rabbits that had received hydralazine in daily dossage of 200mg per kilogram body weight for as long as 4 months. 2. Of the rabbits sensitized with egg white and, in addition, administered with hydralazine, many died suddenly after injections of egg white, but a few rabbits showed anemia, probably hemolytic in type. No LE cell phenomenon or antinuclear factor (ANF) was revealed in this group. 3. Slight leucopenia, albuminuria, hypergamma-globulinemia and increased IgG were found in the rabbits injected with rat anti-rabbit cell nuclei serum. Four rabbits showed nephritis, productive in form at necropsy, with deposition of γ-globulin in glomerular capil laries as revealed by the direct FAT. Weak LE cell phenomenon and ANF were positive in one rabbit. 4. It is presumable that, as in human cases, hereditary factor is impcrtant to produce the models of auto-immune diseases in animals.
発行日
1968-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
80巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
399
終了ページ
409
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/80/3-4/80_3-4_399/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
日本語
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma
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