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ID 17289
Eprint ID
17289
フルテキストURL
Thumnail 90_527.pdf 524 KB
タイトル(別表記)
Studies on anticomplementary activity in systemic lupus erythematosus: Part 2. Experimental studies
著者
天野 哲基 岡山大学医学部第三内科学教室
抄録
The anticomplementary activity (ACA) of immune complexes or DNA was measured, then those data were compared with that in SLE sera. 1. High ACA was detected mainly in γ-GI and β-Gl fractions of SLE sera. 2. DNA (especially denatured DNA) showed high ACA, and the treatment with DNase eliminated its ACA. DNA did not bind nonspesifically to normal γ-Gl. 3. ACA in some SLE sera was reduced after DNase treatment. This treatment worked mainly on ACA of γ-Gl fraction. 4. The procedure of complement inactivation which is employed in measurement of ACA, depressed ACA of cryoglobulin, experimental immune complexes and SLE γ-GI fraction. This indicated that heat aggregation of native IgG could not account for high ACA in SLE sera. 5. The addition of enough amount of complement reduced ACA of immune complexes, but a certain level of ACA was still retained. 6. ACA of insoluble immune complex was much higher than that of soluble immune complex. These data may suggest that ACA in SLE sera originates from the circulating immune complexes, especially DNA-antiDNA antibody immune complexes and this ACA detected is the reflection of only a part of ACA caused by immune reaction in vivo.
発行日
1978-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
90巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
527
終了ページ
536
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/90/5-6/90_5-6_527/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma