ID | 16947 |
Eprint ID | 16947
|
フルテキストURL | |
タイトル(別表記) | Adjuvant therapy of metastatic tumor after excision of main tumor Effect of preoperative intratumoral administration of immunostimulant OK-432 and splenectomy on metastatic tumor
|
著者 |
鳩嵜 明一
岡山大学第一外科学教室
|
抄録 | The acceleration of metastasis after excision of the main malignant tumor and the worsening of the prognosis are sometimes experienced. This phenomenon was simulated in model experiments using Lewis lung carcinoma (3LL) cells and BDF(1) mice. The change of cell-mediated immunity was also studied using delayed type hypersensitivity (DTH) skin reaction. For the purpose of getting a better prognosis, preoperative intratumoral administration of large doses of the immunostimulant OK-432 and splenectomy were studied as possible adjuvant therapy to surgical treatment. Pulmonary metastases and their growth were accelerated after excision of the main subcutaneous tumor, and as a result survival time was not extended. However, DTH increased after the operation. Splenectomy in the early stage was significantly effective on survival, increase of DTH and growthinhibition of the main tumor. The optimum dose of OK-432 in intratumoral administration was 10KE/mouse, and a significant effect was obtained on survival, increase of DTH and growth-inhibition of the main tumor with this dose. Preoperative intratumoral administration of OK-432 and splenectomy in the early stage were useful adjuvant therapy to surgical treatment. A significant effect was obtained on suppression of pulmonary metastases, increase of DTH and survival.
|
キーワード | 補助療法
摘脾
OK-432
術前腫瘍内投与
delayed type hypersensitivity
|
発行日 | 1982-12-30
|
出版物タイトル |
岡山医学会雑誌
|
出版物タイトル(別表記) | Journal of Okayama Medical Association
|
巻 | 94巻
|
号 | 11-12号
|
出版者 | 岡山医学会
|
出版者(別表記) | Okayama Medical Association
|
開始ページ | 1009
|
終了ページ | 1022
|
ISSN | 0030-1558
|
NCID | AN00032489
|
資料タイプ |
学術雑誌論文
|
オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/94/11-12/94_11-12_1009/_article/-char/ja/
|
関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
|
言語 |
日本語
|
著作権者 | 岡山医学会
|
論文のバージョン | publisher
|
査読 |
有り
|
Eprints Journal Name | joma
|