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ID 16947
Eprint ID
16947
フルテキストURL
94_1009.pdf 810 KB
タイトル(別表記)
Adjuvant therapy of metastatic tumor after excision of main tumor Effect of preoperative intratumoral administration of immunostimulant OK-432 and splenectomy on metastatic tumor
著者
鳩嵜 明一 岡山大学第一外科学教室
抄録
The acceleration of metastasis after excision of the main malignant tumor and the worsening of the prognosis are sometimes experienced. This phenomenon was simulated in model experiments using Lewis lung carcinoma (3LL) cells and BDF(1) mice. The change of cell-mediated immunity was also studied using delayed type hypersensitivity (DTH) skin reaction. For the purpose of getting a better prognosis, preoperative intratumoral administration of large doses of the immunostimulant OK-432 and splenectomy were studied as possible adjuvant therapy to surgical treatment. Pulmonary metastases and their growth were accelerated after excision of the main subcutaneous tumor, and as a result survival time was not extended. However, DTH increased after the operation. Splenectomy in the early stage was significantly effective on survival, increase of DTH and growthinhibition of the main tumor. The optimum dose of OK-432 in intratumoral administration was 10KE/mouse, and a significant effect was obtained on survival, increase of DTH and growth-inhibition of the main tumor with this dose. Preoperative intratumoral administration of OK-432 and splenectomy in the early stage were useful adjuvant therapy to surgical treatment. A significant effect was obtained on suppression of pulmonary metastases, increase of DTH and survival.
キーワード
補助療法
摘脾
OK-432
術前腫瘍内投与
delayed type hypersensitivity
発行日
1982-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
94巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1009
終了ページ
1022
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/94/11-12/94_11-12_1009/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
日本語
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma
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