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ID 16616
Eprint ID
16616
フルテキストURL
Thumnail 96_1151.pdf 1.66 MB
タイトル(別表記)
Studies on the pathogenesis of sarcoidosis Part I. Studies on bronchoalveolar lavage fluid
著者
小林 洋三 岡山大学医学部第2内科教室
抄録
The present study was designed to investigate the local immunity and pathological state of sarcoidosis. Cell populations and angiotensin converting enzyme (ACE) activity were examined in the fluid obtained by bronchoalveolar lavage (BAL) of 28 patients with sarcoidosis and 31 healthy volunteers. The proportion and number of lymphocytes in BAL fluid were significantly higher in patients with sarcoidosis than in healthy volunteers. Furthermore, the number of T lymphocytes and B lymphocytes were increased. The cell number in BAL fluid was also higher in non-smokers with sarcoidosis than in healthy non-smokers. The ACE activity in bronchoalveolar lavage fluid (BALF-ACE activity) was highly elevated in patients with sarcoidosis as compared with healthy volunteers and correlated with the number of macrophages in BAL fluid of non-smokers with sarcoidosis (r=0.474, p<0.05). The elevation of BALF-ACE activity was suggested to be due to alveolar macrophages. In smokers with sarcoidosis and healthy volunteres who smoked, the number of cells and macrophages in BAL fluid was markedly increased, while the number of lymphocytes was not affected by smoking. It was concluded that lymphocytes, mainly T lymphocytes which play a major role in forming granuloma, were incerased in patients with sarcoidosis and that high BALFACE activity was probably due to activated macrophages and epithelioid cells in sarcoid granulomas of the lung.
キーワード
sarcoidosis
bronchoalveolar lavage
angiotensin converting enzyme
lymphocyte
発行日
1984-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
96巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1151
終了ページ
1161
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/96/11-12/96_11-12_1151/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
9
Eprints Journal Name
joma