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ID 16390
Eprint ID
16390
フルテキストURL
Thumnail 95_1003.pdf 3.16 MB
タイトル(別表記)
Studies on anticomplementary activity in primary glomerular disease.
著者
高橋 香代 岡山大学医学部第三内科学教室
抄録
The anticomplementary activity (ACA) of the sera of 81 patients with primary glomerular disease was studied. ACA was mesured by a complement consumption test, and the ACA of alternaive pathway was measured by a homolysis inhibition test, using rabbit red blood cells in EGTA buffer. In acute glomerulonephritis, the ACA of the sera with high levels of antistreptokinase and γ-globulin was significantly higher than that of the sera with low levels. The ACA of the sera of sclerosing glomerulonephritis patients was significantly higher than that of the sera of patients in other histlogical categories based on light microscpy. There were no relationships between immunofluorescence findings in the glomerulus and the ACA of the sera of patients with primary glomerular disease. In chronic glomerulonephritis, the ACA of the sera correlated with the levels of BUN, S-creatinine, PSP (15 min.) and Ccr significantly (p<0.001). The sera from uremic patients showed predominantly high ACA and contained heat stable factors (m.w.; more than 25000 daltons) witch were able to activate the classical complement pathway. There observations suggested that the anticomplementary factors in acute glomerulonephritis might be immune complexes and those in uremia might be unknown uremic toxins.
キーワード
糸球体腎炎
腎不全
尿毒物質
補体
抗補体活性
発行日
1983-10-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1003
終了ページ
1016
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/9-10/95_9-10_1003/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
13
Eprints Journal Name
joma